![]() It has an ambient light sensor that adjusts the brightness according to the light conditions, or you can set a Sunrise Alarm that wakes you up with gradually increasing bright light from the display. Instead, it’s focused on telling you the time, checking the weather or viewing calendar events. What’s so good about Lenovo’s Smart Clock is the stuff it’s missing: there’s no front-facing camera or photo display mode, and the 4in, 800 x 480 screen isn’t designed for browsing the web or watching video. Lenovo Smart Clock: Best Google smart clock The best alarm clocks you can buy in 2023 1. Of course, you might not be comfortable with Alexa listening to you in the bedroom, let alone catching your early-morning hair with a built-in camera. Some manufacturers, such as Amazon and Lenovo, are building smart speakers or displays that double up as alarm clocks, waking you up while giving you all the usual info, music, radio and smart home controls. With smart TV sticks, smart speakers and smart lighting everywhere you look, it’s no surprise that even alarm clocks are getting smart these days. If you want to be able to check the time without leaning over the bedside table, these are a great choice. Some alarm clocks move beyond standard displays and project the time onto the wall or ceiling for a larger, more easily readable display. For those of you who opt for a digital display, you’ll want to look for a display that’s easy on the eyes and has an acceptable brightness level, which will vary from device to device – bear in mind, though, that those with automatic display brightness will stop your alarm clock lighting up your bedroom at night. You can easily find digital alarm clocks with LCD and LED displays these days, as well as retro designs with the traditional clock face and analogue quartz technology. ![]() What kind of display do I go for?īest pillow 2023: Our favourite microfibre, memory foam and down pillows In addition to the standard radio and buzzer options, some alarm clocks allow users to dock a media player such as a smartphone to play content from the device, or connect a USB stick, for a customised way to start the day. It’s also worth bearing in mind that a power outage can disrupt a mains-powered alarm clock, so ones equipped with a battery backup are well worth paying a little extra for. Obviously, if you’re on your travels you will want long-lasting battery models that make it clear when the batteries need changing, while those looking for a clock to put on a bedroom table will prefer ones that run off mains power. Do I want a mains-powered or battery-powered alarm clock?Īn alarm clock’s key power source is definitely something you need to consider. Meanwhile, more expensive alarms will illuminate your bedroom with a calming light to simulate the feeling of waking up under canvas at sunrise. Do you want to wake up to your favourite breakfast radio station or would a traditional bell get you out of bed quicker? Some alarm clocks have come into the 21st century with “Humane Waking Systems” – that’s where buzzers start off at a low volume and get louder. How to choose the best alarm clock for you What kind of alarm clock should I buy? Best Alexa smart clock: Echo Show 5 2nd gen | £45.Best for heavy sleepers: Sonic Bomb | £43.Best stylish alarm clock: Newgate Wideboy | £45.Best twin bell alarm clock: Newgate Charlie Bell | £25.Best wake-up light for £50: Lumie Sunrise Alarm | £50. ![]() Best Google smart clock: Lenovo Smart Clock | £79.And with only one job to do, you can be certain of one thing: these alarm clocks won’t let you sleep in when you need to be up and out. No matter what your sleeping habits are, there’s an alarm clock out there that will do the job for you. Some of them are designed to rouse heavy sleepers with the kind of racket that even the most loud-mouthed of smartphones would struggle to imitate, and others even claim to aid us in getting a better night’s rest. No longer is it good enough for them just to make a loud noise. In order to survive the smartphone revolution, alarm clocks have had to evolve. For anyone who’s ever found themselves let down by their mobile phone, however, or for those who want something a little more high tech, a dedicated alarm clock is a sound investment. Since the arrival of the smartphone, which has now become everyone’s constant companion, quite a few of us have long since chucked our old-school alarm clock across the bedroom directly into the bin. Some might argue that we really don’t need alarm clocks any more.
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![]() ![]() The first Category ‘Essentials’ is very similar to the editing tools we can find in Lightroom or Adobe Camera RAW. See also: 10 Tips for Stunning Portrait Photography. ![]() Their text is white compared to the rest (grey) which was not modified. In this example, the Light, AI Enhance and Details Enhancers panels were modified. With this, you can brush out parts that you don’t want to be included in the image, or simply add a gradient mask.Įssentials panel in Luminar. Photo by: 'Albert Dros'.Īnother thing you should know is that every panel you’ve done edits to will light up white instead of grey, so you can easily see that you’ve modified these panels. Almost every adjustment has an ‘edit mask’ button. This is why we’ll mostly talk about 1 in this guide.Įdit Mask in Luminar. Photo by: 'Albert Dros'.īefore we start discussing all of the interesting categories and panels, it’s essential to know that you can always mask out your adjustments with a mask. We’ll go over most of the editing tools in Luminar and explain how to use them in your image. This guide will be mostly about processing your image. See also: 11 Tips to Help You Capture Stunning Landscape Photographs.At the Canvas panel, you can remove distortion, straighten lines, de-vignette (some lenses standard have vignetting) and change the geometry of the image. You can create multiple (adjustment) layers to put more edits. Think of multiple gradients on the same sky, etc. Layers are useful for when you want to stack multiple edits on top of each other. Yes, Luminar can even use Layers, just like Photoshop. On the top right, you can see the Layers and Canvas buttons. The crop tool for if you need to crop in your image a bit or slightly rotate it. Use them to check your original file compared to your edits. Here you can find the before/after buttons. Simply click ‘save new look’ on the bottom right to save your own look. You can also save your own edits as a Look so you can apply the same edits to different photos. I also created a Looks pack specifically designed for forests. Luminar looks can be great if you’re still a beginner at processing and want to see how different functions in Luminar are used to get certain results. You can find more looks on Luminar’s website. Luminar comes with a bunch of free looks. They’re presets that you can use to apply a bunch of edits to your photos right away to get fast results. You can find the so called ‘Luminar Looks’ here. You see the essentials panel normally, and you can click the other buttons for the other panels: Essentials, Creative, Portraits and Professional. Photo by: 'Albert Dros'.Īll the tools in Luminar are categorised in different categories. When you import an image, you will see the following interface. Luminar’s basic interface is very straightforward and easy. This workflow is preferred by most photographers but Luminar also offers their own cataloguing tool which gets better with every update. After you do your edits in Luminar -> save and pop right back into Lightroom. Using Luminar as a plugin is very convenient, as you can do very basic edits in Lightroom first (lens corrections, etc) and then simply right click -> edit in -> Luminar. See also: 8 Tips to Improve Your Landscape PhotographsĪs mentioned above, Luminar can be used as standalone software or as a plugin for Photoshop and Lightroom.Luminar is basically similar software and offers most functions and modules of the Nik bundle, but with more regular updates. You might know the Nik Effex bundle, especially Color Efex, previously owned by Google (now by DXO). Luminar offers a lot of powerful, in-depth tools that are also appealing for advanced users. But I want to emphasise the fact that Luminar is not about getting results in a few clicks, nor is it just about replacing a sky. It lets you replace the sky of your photo in just a few clicks and works incredibly well. The newest function that Luminar is ‘famous’ for is the sky replacement tool. Discover these 11 Tips to Help You Capture Stunning Landscape Photographs.Check out these 15 Tips for Monochrome Photography.As Luminar has a lot of tools to make it extremely simple to get quick decent results, it can also go very in depth and offers a lot of great tools for advanced editing. This guide describes both basic and advanced editing in Luminar. In this guide, we’ll only be discussing the processing part. Luminar also offers a library module and can be used as complete stand-alone software to both catalogue and edit your photos. This guide is aimed at photographers seeking to process their photos in Luminar. ![]() The company began with a brick-and-mortar training center known as the American Barista and Coffee Workshops, and later added two online programs: Virtual Coffee, a program for the home barista, and Online Barista Training, which caters to professionals. Espresso USA, Milletto is a prolific contributor to the modern coffee scene and has been officially designated a "Coffee Luminary" by the Specialty Coffee Association of America.īellissimo, which Milletto operates in partnership with his son Matt, has created many educational tools and programs over the years. Single courses cost between $100 and $200 if purchased a la carte an individual subscription costs about $15 per month a team subscription, which supports up to 20 baristas, costs about $100 per month and a 50-barista team subscription sells for about $200 per month.īellissimo Coffee Advisors is primarily the work of Bruce Milletto, who founded this Portland, Oregon-based company in 1991. You can purchase courses individually or subscribe to the site for unlimited access to all the material. Specialized Courses consist of Terroir, Processing, and a class titled "The Decision Tree," a free course that aims to help coffee professionals confront climate change.īarista Hustle's site has a beautiful, contemporary design, and all the courses have free previews where you can get a feel for the quality and style of the content. Advanced Courses cover Advanced Coffee Making, Milk Science, The Water Course, Coffee Quality Control, and Advanced Espresso. The Baseline courses include two basic coffee brewing classes titled Percolation and Immersion, as well as Barista One-the company's flagship 20-hour class focusing on modern espresso preparation. Based in Australia, the very extensive website is run by highly accomplished barista Matt Perger.īarista Hustle offers over a dozen courses that are divided into Baseline, Advanced, and Specialized levels. If you're looking for an exclusively online barista training program, check out Barista Hustle. Prices range from around $130 for a home barista lesson to roughly $2,600 for the multi-day professional curriculum. The home barista classes are half-day sessions, covering basic espresso competence, milk steaming, and latte art. The professional courses include an intensive, two-day barista skills seminar and a five-day total immersion class that covers hot and iced beverages, operations training, a consulting package, and a tour of Seattle's top cafes. Seattle Barista Academy offers two professional courses, as well as two courses for the casual home barista. Second, Seattle's highly developed coffee scene-born of its long history and intense marketplace competition-is an endless source of inspiration for the actualizing coffee professional. First, all the training is in person, allowing for hands-on learning with professional commercial equipment. ![]() Seattle Barista Academy's training offers the developing barista two considerable advantages. In 2003, Burgess did his part to usher in the third wave, founding the Seattle Barista Academy, an institution dedicated to facilitating the relentless quest for quality that defines our contemporary coffee scene. During the early 1980s in Seattle, Burgess played a prominent role in the city's so-called "second wave" coffee scene, manufacturing coffee carts, importing espresso machines, and supporting entrepreneurs. Prices for courses are set by the ASTs and therefore vary.īob Burgess is one of the original builders of modern American cafe culture. You can also use the portal to find ASTs (Authorized SCA Trainers) in your local area. Use the filters to find the classes in your specific area of interest. To get started, register an account in the member portal, then search the course calendar. The Intermediate Level focuses on working knowledge, and the Professional Level delves into specialist knowledge. Each module is split into three levels: The Foundation Level provides a basic introduction to the module's topic. The curriculum is composed of six modules: Introduction to Coffee, Barista Skills, Brewing, Green Coffee, Roasting, and Sensory Skills. The SCA's course is called the Coffee Skills Program. Boasting thousands of members and certified trainers located all over the world, the SCA is the preeminent organization dedicated to pursuing and maintaining the highest standards in the specialty coffee industry. The SCA performs a variety of functions in today's complex coffee world, including scientific research, economic analysis, community organization, and education. ![]() With roots going back to 1982, the Specialty Coffee Association (SCA) is the leading trade association in the industry. Explore our range and discover the perfect model for you. The LG WashTower™ also comes with sanitary cycles and Allergiene™ technology to help remove stains, bacteria and allergens giving you cleaner, fresher fabrics. The smart washer dryer comes with built-in sensors, powered by innovative AI technology that can detect textures and load weight to optimise your programme settings for you. Using the ThinQ® App you can control laundry from anywhere and with the latest in LG technology, you no longer need to worry about sorting fabrics and choosing cycles. Thanks to the integrated technology and ThinQ® App, you can wash smarter and revolutionise the way you do laundry forever. LG. So if you’re looking for an all-in-one laundry solution, the LG laundry Tower is the best choice. Its innovative and attractive design, cutting-edge technology, and efficiency make doing laundry much faster and enjoyable. To install a side venting kit in your dryer, first remove the screws securing the main. The LG WashTower is a smart and efficient appliance that can keep up with your busy lifestyle. Tags related: Lg Washer Settings Instructions Front Loader, Lg Washtower Installation Manual, Lg Washer Settings Instructions, LG Electronics Induction Cooktops User Manuals, LG Pedestal Washer. As with any repair, you should unplug the appliance before beginning. For side venting, you will need WashTower with Center Control 4. LG STUDIO WSEX200HNA Center Control 5.0 cu. 95: Stainless Steel Braided Washer Hoses 4 Ft : 19. To properly experience our LG.com website, you will need to use an alternate browser or upgrade to a newer version of internet Explorer (IE10 or greater). PDF User Manual for Lg Wash Tower Installation Instructions. Learn how to use, update, maintain and troubleshoot your LG devices and appliances. Please note that it can also be configured to vented side on some models. ![]() ![]() Your new dryer is shifted to vent to the rear. LG STUDIO WSEX200HNA Center Control 5.0 cu. Clean old ducts before installing the dryer. PDF User Manual for Lg Wash Tower Installation Instructions. Our smart WashTowers™ are designed to conserve space and boast large capacity loading capabilities to help you conquer the mountain of laundry quicker. LG WashTower ThinQ Features and Settings. The exhaust duct run should be as short as possible. With the LG WashTower™ you can get all the performance you need, packed into a convenient and space-saving design. If you’re looking for a large capacity washing machine or dryer, but you’re concerned about space, look no further. ![]() Looking for suggestions if there is a better way.
![]() CNELNs might be promising nanosystems for oral delivery of CUR to satisfy clinical requirements.Īnti-cancer cytotoxicity Characteristics In situ absorption In vivo kinetic property Nanoemulsion based lipid nanosystems.Ĭopyright © 2016 Elsevier B.V. This book brings together a number of key biopolymer and biodegradable plastics topics in one place. ![]() CNELNs had stronger inhibitory effects on the viabilities of A549 cells than that of free CUR. Biopolymers and Biodegradable Plastics are a hot issue across the Plastics industry, and for many of the industry sectors that use plastic, from packaging to medical devices and from the construction indusry to the automotive sector. CNELNs markedly improved the oral bioavailability of CUR which was probably due to the increased gastro-intestinal absorption. CNELNs inhibited A549 growth in a dose- and time-dependent manner. Zhou, Qiansujia Yin, Si-Yong Zheng, Dong-Song Zhang, Wen-Wen Zhang, Su-Zhen Gu, Qing You, Shu-Li: Enantioselective Synthesis of Axially Chiral. 1 of 5 stars 2 of 5 stars 3 of 5 stars 4 of 5 stars 5 of 5 stars. The relative bioavailability of CNELNs to free CUR was 733.59%. His focus is to build an AI-driven product to characterize patients and. ![]() The absorption constants and effective permeabilities of CNELNs in different gastro-intestinal tracts increased 2.29-4.04 times and 4.06-8.27 times that of curcumin (CUR), respectively. Jingqing Zhang () is the technical co-founder and Head of AI at Pangaea Data. This book will fascinate students and scholars of Chinese politics, and is essential reading for anyone concerned about China’s political future. The inhibitory effects of CNELNs on human lung cancer A549 cell growth were determined using MTT assay. A Confucian Constitutional Order provides a new standard for evaluating political progress in China and enriches the dialogue of possibilities available to this rapidly evolving nation. The gastro-intestinal absorption, in vitro release and in vivo kinetic property of CNELNs were investigated using an in situ perfusion method, a dialysis method and a concentration-time curve based method, respectively. The CNELNs were first fabricated by loading water-in-oil nanoemulsions into lipid nanosystems using a nanoemulsion-film dispersion-sonication method. The goal of this study was to assess the enhanced elementary characteristics, in vitro release, anti-cancer cytotoxicity, in situ absorption and in vivo bioavailability of a novel nanoemulsion based lipid nanosystems containing curcumin (CNELNs) when administered orally. Description Multiscale Modeling of Additively Manufactured Metals: Application to Laser Powder Bed Fusion Process provides comprehensive coverage on the latest methodology in additive manufacturing (AM) modeling and simulation. ![]() His penchant for experiments and inventiveness have been captured in hit shows such as Rocket City Rednecks and 3 Scientists Walk Into a Bar, as well as HISTORY’s The Tesla Files and Ancient Aliens. Taylor has published over 25 papers, four textbooks (including Alien Invasion), and has authored or co-authored over 20 best-selling science fiction novels. For the past 35 years, Taylor has worked on various programs for the Department of Defense, NASA, and the intelligence community in areas that include advanced propulsion concepts, quantum teleportation, advanced sensors, space telescopes, space-based beamed energy systems, future combat technologies and systems, and next generation space launch concepts. Travis Taylor is a licensed professional engineer who holds Ph.Ds in Optical Science and Engineering and Aerospace Systems Engineering, as well as Masters in Physics, Mechanical and Aerospace Engineering, and Astronomy and a B.S. Please note that autographs will not be available.ĭr. Only a limited number of tickets will be available for each event. This upgrade experience can be purchased by all ticket holders, regardless of seating location. Immediately following the show, fans who purchase this add-on will have the one-of-a-kind opportunity have their photo taken with all of the featured Ancient Aliens contributors, captured by a professional photographer. Take home a piece of the experience with the exclusive VIP photo package, available only through the Ancient Aliens Live Tour. ![]() Travis Taylor will not appear at shows between September 14 and November 5. ![]() Travis Taylor, UK government UFO investigator Nick Pope, and real-life Indiana Jones, David Childress, as they discuss thought-provoking extraterrestrial theories on fan-favorite topics from Ancient Egypt to the moon, paving the long road to Disclosure. Tsoukalos, investigative mythologist William Henry, aerospace engineer and intelligence expert *Dr. The ninety-minute live experience celebrates the long-running program Ancient Aliens on The HISTORY Channel and features leading Ancient Astronaut theorist Giorgio A. Ancient Aliens LIVE: Project Earth is an experiential extension of Ancient Aliens that explores the theory that extraterrestrials have visited Earth for millions of years. ![]() ![]() It is interesting to find that the Ray-Ban Wayfarer earns its well-deserved reputation as "unmistakable". It comes with several types of lenses you can choose from: gradient, polarized, and simple matte. Even though the style itself has undergone several changes over the decades, the essence has remained unchanged. It is the iconic silhouette that put the style in the design department of the eyewear. Without a doubt, the tear-shaped of this Ray-Ban sunglasses and its thin metal frame prove itself as a fashionable combination that inspires countless variations in other parts of the world. Tom Cruise even popularized this legendary Ray-Ban design as his signature style move in the popular movie, "Top Gun". Simple and sophisticated, it is little wonder that the Ray-Ban Aviator Classic has been hailed as a stylish design that will never run out of style. Originally, this pair of sunglasses were designed for American aviators in 1937. ![]() Ray-Ban Aviator ClassicĪs one of the most iconic Ray-Ban sunglasses globally, the Ray-Ban Aviator Classic sunglasses are a timeless model that combines great aviator styling with exceptional quality, performance, and comfort. Here is a helpful guide which lists the top Ray-Ban sunglass designs that redefine the concept of being cool. When it comes to sunglasses, the popular Ray-Ban sunglasses are seen as top choices because they exude simplicity and sophistication in the same breath. Moreover, Ray-Ban delivers award-winning designs every aspiring fashionista loves to wear to complement their outfit choices. With its legendary reputation, Ray-Ban Malaysia has contributed to the idea of fashionable sunglasses that still dominates the fashion world. 22 standard rim-fire cartridges (no 22 magnums) and shotguns with shot no larger than No. Legal weapons for hunting from one-half (1/2) hour after sunset to one-half (1/2) hour before sunrise are restricted to handguns or rifles using no larger than. For legal deer see "Hunting Deer" for legal sizes and bag limits. Raccoon, fox, opossum, beaver, and bobcats may be legally hunted at night, with or without the use of a light, and with dogs, except during the spring turkey season. Legal shooting hours for migratory birds are one-half (1/2) hour before sunrise to sunset. Legal shooting hours for resident game are one-half (1/2) hour before sunrise to one-half (1/2) hour after sunset. All exempt licenses previously issued for DISABILITIES are null and void.Īny person who obtains a license under an assumed name or makes a materially false statement to obtain a license is guilty of a felony and shall be subject to a fine of two thousand dollars ($2,000) or may be imprisoned for a term of one (1) year or both. Residents exempt based on this criteria are required to have proof of their age, residency, disability status or other physical impairment in their possession while engaged in hunting and fishing activities. Residents who are v isually impaired, paraplegic, a multiple-amputee, adjudged totally disabled by the Social Security Administration or totally service-connected disabled by the Veterans Administration are not required to purchase a HUNTING OR FISHING LICENSE. It is unlawful to issue a hunting license to any person in this age group without proof of completion of the hunter education course. If it is determined that the holder was not entitled to issuance or obtained the license or hunter education certificate by fraudulent means, the license will be revoked or canceled. Non-Resident - All non-resident hunters, except minors under the age of sixteen (16), are required to obtain a hunting license while hunting in the State of Mississippi.Īll persons born on or after January 1, 1972, must satisfactorily complete a hunter education course approved by the Department of Wildlife, Fisheries, and Parks before purchasing a Mississippi hunting license. ![]() Any person sixty-five (65) or older, or any person otherwise exempted from obtaining a hunting license, must have documentation with him/her at all times while hunting as described in #3 (Exemptions). Resident - Each resident of the State of Mississippi ages sixteen (16) to sixty-four (64), must obtain a hunting license, except while hunting on lands titled in his name.Contact the MDWFP or area personnel for information about these areas. Department of Wildlife, Fisheries, and Parks Wildlife Management Areas are subject to special seasons and regulations which may vary from statewide seasons and regulations. Landowner permission is required to hunt, fish or trap on the lands of another. General Hunting Regulations & Requirements Hunters can either (a) log the harvest into the MDWFP reporting application on a smartphone (b) enter the harvest via the Game Check website at or (c) call the Game Check reporting phone line at 1-800-BE-SMART. There are three ways to complete the Game Check process and receive a confirmation number. ![]() Before moving a turkey from the harvest location, hunters must, at minimum, document their name and date on the harvest reporting record. The reporting record may be either (a) the MDWFP reporting application on a smartphone with the hunter's profile and subsequent harvest history (b) a paper copy of the MDWFP harvest reporting record or (c) provided by the hunter. As part of the Game Check process, all turkey hunters are required to carry a current harvest reporting record while spring turkey hunting. ![]() All turkeys harvested during the spring turkey season must be reported to the Mississippi Department of Wildlife, Fisheries, and Parks Game Check system by 10 p.m. The data cutoff for the primary analysis occurred on November 25, 2020. No other potential conflict of interest relevant to this article was reported. Zaks, being employed by and owning stock options in Moderna. Miller, being employed by and owning stock and stock options in Moderna and Dr. Ivarsson, being employed by and owning share options in Moderna Dr. Han, being employed by and owning stock and stock options in Moderna Dr. Leav, Deng, and Zhou being employees of Moderna Dr. Knightly, being employed by and owning stock and stock options in Moderna Drs. Pajon, being employed by and owning stock in Moderna Dr. Bennett, being employed by and owning stock and stock options in Moderna Dr. Graham, holding pending patent WO/2018/081318 on prefusion coronavirus spike proteins and their use and pending patent 62/972,886 on 2019-nCoV vaccine Dr. Neuzil, receiving grant support from Pfizer Dr. Creech, receiving grant support from Merck, consulting fees from Horizon Pharma and GSK, and fees for serving on a data and safety monitoring board from Astellas Dr. Rouphael, receiving grant support from Pfizer, Merck, Sanofi–Pasteur, Eli Lilly, and Quidel Dr. Baden reports being funded by the NIH to conduct clinical trials in collaboration with Crucell/Janssen and Moderna Dr. (Funded by the Biomedical Advanced Research and Development Authority and the National Institute of Allergy and Infectious Diseases COVE number, NCT04470427.).Ĭopyright © 2020 Massachusetts Medical Society.ĭr. Aside from transient local and systemic reactions, no safety concerns were identified. The mRNA-1273 vaccine showed 94.1% efficacy at preventing Covid-19 illness, including severe disease. Serious adverse events were rare, and the incidence was similar in the two groups. Moderate, transient reactogenicity after vaccination occurred more frequently in the mRNA-1273 group. Severe Covid-19 occurred in 30 participants, with one fatality all 30 were in the placebo group. Efficacy was similar across key secondary analyses, including assessment 14 days after the first dose, analyses that included participants who had evidence of SARS-CoV-2 infection at baseline, and analyses in participants 65 years of age or older. person-years 95% confidence interval, 48.7 to 65.3) and in 11 participants in the mRNA-1273 group (3. Symptomatic Covid-19 illness was confirmed in 185 participants in the placebo group (56. More than 96% of participants received both injections, and 2.2% had evidence (serologic, virologic, or both) of SARS-CoV-2 infection at baseline. The trial enrolled 30,420 volunteers who were randomly assigned in a 1:1 ratio to receive either vaccine or placebo (15,210 participants in each group). The primary end point was prevention of Covid-19 illness with onset at least 14 days after the second injection in participants who had not previously been infected with SARS-CoV-2. Persons at high risk for SARS-CoV-2 infection or its complications were randomly assigned in a 1:1 ratio to receive two intramuscular injections of mRNA-1273 (100 μg) or placebo 28 days apart. This phase 3 randomized, observer-blinded, placebo-controlled trial was conducted at 99 centers across the United States. The mRNA-1273 vaccine is a lipid nanoparticle-encapsulated mRNA-based vaccine that encodes the prefusion stabilized full-length spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19. Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. |
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